Wicker is opposed by Republicans E. Allen Hathcock of Stewart and Robert Maloney of Madison, with Democrats putting up Albert N. Gore Jr. of Starkville and Roger Weiner of Clarksdale.
Republican U.S. Rep. Steven Palazzo of Biloxi will face GOP challengers Cindy Burleson and Ron Vincent, both of Hattiesburg. Democrats include Michael Herrington of Hattiesburg and Joshua LaRose of Harrison County.
U.S. Rep. Alan Nunnelee will meet Eupora's Henry Ross and Robert Estes of Southaven in the GOP primary, while Democrats include Brad Morris of Oxford and Mark DuVall of Mantachie. There are reports DuVall will drop out of the race.
U.S. Rep. Bennie Thompson of Bolton is expects to face Heather McTeer of Greenville on the Democratic side, while Republican Bill Marcy of Vicksburg has also qualified.
NEMS Daily Journal staff contributed to this report.